1. neutropenia is usually defined as an absolute neutrophil count (ANC) <1500 or 1000 cells/microL, 

2. severe neutropenia is usually defined as an ANC <500 cells/microL or an ANC that is expected to decrease to <500 cells/microL over the next 48 hours [1].

3. Profound neutropenia is defined as an ANC <100 cells/microL. 

# single oral temperature of ≥38.3°C (101°F) or a temperature of ≥38.0°C (100.4°F) sustained over a one-hour period