1. The shortest pulmonary tuberculosis treatment regimen is 4 months, starting with an intensive phase of isoniazid, rifapentine, pyrazinamide, and moxifloxacin for 8 weeks followed by a continuation phase of rifapentine, isoniazid, and moxifloxacin for 9 weeks. no pregnancy no CV no Liver no CKD 

2. initial intensive 8-week treatment phase for active tuberculosis infection (daily rifampin, isoniazid, pyrazinamide, and ethambutol) and is ready to begin the continuation phase of treatment consisting of isoniazid and rifampin daily to complete a total treatment duration of 6 months : criteria

• Patient tolerance for the treatment regimen
• No interruption in treatment
• A drug-susceptible isolate
• An initial chest radiograph showing no evidence of cavitation
• A negative acid-fact bacilli smear and culture at the end of the 8-week initial treatment phase
• The treatment recommendation is similar for persons living with HIV/AIDS who continue antiretroviral therapy during antituberculosis treatment for drug-susceptible pulmonary tuberculosis.

ACP MKSAP